Usually continue until healing is progressing well or site is ready for grafting. Reapply cream to any areas from which it has been removed by patient activity and reapply immediately following hydrotherapy.Ĭontinue applying cream as long as there is a possibility of infection unless a clinically important adverse reaction occurs. Adults Prevention and Treatment of Burn Infections TopicalĪpply 1% cream in a thickness of approximately 16 mm (1/16 inch) 1 or 2 times daily cover burn area with cream at all times. DosageĪvailable as silver sulfadiazine dosage expressed in terms of the salt. If possible, bathe patient daily to aid in debridement.ĭressings usually not required but may be used. Topical cream should not be applied to the eye. Topically apply 1% silver sulfadiazine cream after appropriate regimens for burn care have been promptly instituted, including control of shock and pain.Īdministration Topical Administration CreamĪpply 1% cream topically to cleansed, debrided burn wounds under sterile conditions (e.g., using a sterile-gloved hand). Silver Sulfadiazine Dosage and Administration General Softening action of silver sulfadiazine cream may aid in eschar removal and preparation of wound for grafting. Unlike mafenide, a carbonic anhydrase inhibitor, silver sulfadiazine does not alter acid-base balance and does not have a limited duration of therapy and area of topical application. Mafenide appears to penetrate burn eschar better than silver sulfadiazine and may be more effective in minimizing the growth of bacteria and early treatment of wound sepsis. Silver sulfadiazine cream is used topically as adjunct therapy to prevent and treat wound sepsis in second- and third-degree burns after resuscitative measures (e.g., control of shock and pain, correction of electrolyte imbalance) have been instituted.Ĭontrol of bacterial growth may prevent conversion of deep, second-degree (partial-thickness) wounds to third-degree (full-thickness) wounds by sepsis.Ĭoncomitant administration of appropriate systemic anti-infective agents may be necessary if infection present or suspected.Īlthough controlled, comparative studies are lacking, silver sulfadiazine and mafenide are considered by many clinicians to be among the topical anti-infective agents of choice in burn patients. Uses for Silver Sulfadiazine Prevention and Treatment of Burn Infections Sulfonamide synthetic anti-infective agent. This medicine may rarely stain skin brownish gray.Drug class: Local Anti-infectives, Miscellaneous The results of some tests may be affected by this medicine. These could be symptoms of a blood disorder.Ĭheck with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine.īefore you have any medical tests, tell the medical doctor in charge that you are using this medicine. If your skin infection or burn does not improve within a few days or weeks (for more serious burns or burns over larger areas), or if it becomes worse, check with your doctor.ĭo not use this medicine for a skin problem that has not been checked by your doctor.Ĭheck with your doctor right away if you have the following symptoms while using this medicine: bleeding gums, cough or hoarseness, fever with or without chills, painful or difficult urination, sores, ulcers, or white spots on the lips or in the mouth, unusual bleeding, bruising, or weakness, or yellow skin or eyes.
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